Is it anyhow possible to set the Default font for all users / Software (Excel, Word, PowerPoint,...)
I found this: https://support.office.com/en-us/article/Change-the-default-font-2f50603b-9886-47e4-a483-48ac5ab8016...
What does it direct in Word for example. But I want to set it over Office 365 console
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No this isn't possible, nothing built-in to Office 365 will set the default font for apps per your suggestion. There may be ways to do this by other means such as the suggestions here.