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Dear John Gruber​ RyanSteele-CoV​ Jack36​ 

Thank you for your help.

The issue is the web content filtering and windows smart screen not sure who activated it and added some urls to it.

https://learn.microsoft.com/en-us/defender-endpoint/indicators-overview#ipurldomain-indicators

https://learn.microsoft.com/en-us/defender-endpoint/web-content-filtering

It seems like a sync issue between Microsoft Edge SmartScreen and Microsoft Defender for Cloud Apps (MCAS). Sometimes, local security updates change how SmartScreen interprets unsanctioned tags, even if they aren't visible in the dashboard. Have you checked if there are any specific 'Network Protection' events in the local Windows Event Viewer? This might clarify if it's a policy push or a standalone update issue.

Just to be clear: if you navigate to https://security.microsoft.com/cloudapps/app-catalog?tag=eq(Unsanctioned%2C) , you don't see "Microsoft Word Online" in the list?

There was an issue recently (DZ1231199) which, for us at least, resulted in a number of apps being unexpectedly tagged as "Unsanctioned" and blocked in Edge. Even once the issue was supposedly resolved, we had to manually remove the tags from the apps to restore access.

Thank you John Gruber​  I have checked those places, I was not able to see any trace of it, however my research and troubleshooting led me to the smartscreen for Microsoft Edge feature in windows security. when I turn it on it happens, when I turn it off it stops. the question is what changed? how and why is the behavior like this? was there an update? is this linked to MCAS?

Two places I can think of:

1. Defender for admin center > system > settings > endpoints > web content filtering > check for policies here
2. Defender for admin center > Cloud Apps > Cloud app catalog > Find the app > click sanction