Windows 11 keeps updating Prolific driver 184.108.40.2067 ,which works fine , with driver 220.127.116.11 which does not work at all for my serial port. When you look at driver 18.104.22.168 it says " Please install corresponding PL 2303 driver to support windows 11 and further OS . " I have been installing the working driver with Prolific's " PL2303_prolific_DriverInstaller_V1_12.0 " . It works fine until Windows updates it again with the bad driver.
To prevent Windows Update from automatically installing the incorrect driver I had to edit my Group Policy settings to not update drivers. I tested by checking for updates and it did not include the drivers this time. If your pc is on a domain, then your administrator may have control over your group policy settings and might need to make the change for you.