Computer Unresponsive after screens turned off overnight & USB Issue.

This has always been a problem but I do not like having to hard shut down every single morning...

Running 3 screens. I can leave them on all night, wake up 9 hours later, and the pc will run as normal.
If I turn them off for the night I come back to an unresponsive computer.
The screens are black but do not say "No Signal"
Ctrl Alt Del will sometimes wake up a screen but nothing happens.
The mouse doesn't appear.
Win Ctrl Shift B does nothing at all.
Pressing the Power button does nothing. I have to hold it until the rig shuts off.
All sleep and power saving options are off, as far as I know.
It's all set to NEVER or disabled.
Ultimate Performance is the current power plan.
GPU drivers are new, not repaired or fast/minimum install.

The only OTHER remaining issue is USB devices will lose signal if I plug too many in directly to the motherboard.
There's 3 ports on top of the case. If I use more than one I lose connection and sometimes nothing reconnects.
Same problem directly on the motherboard. I can plug in 2 devices no issue but a 3rd will cause everything to lose connection.
To alleviate this issue I'm using a USB hub.

The USB issue has been a problem for years and did the same thing on an AM3 platform. Nobody can give me a straight answer on how to fix that but it's been a few years so maybe someone found a solution by now?