Can I upgrade my Windows 11 license from home to pro without reinstalling?

I would try to avoid reinstalling anything if the current Windows 11 Pro installation is already set up with all of your accessibility settings and applications working the way you need them.

From what I understand, Windows 11 Pro can be activated without reinstalling Windows. If Pro is already installed, you should normally be able to go through the Activation settings and enter a valid Windows 11 Pro product key. That would be much less disruptive than changing the edition or starting over with Windows 11 Home.

I also wouldn't recommend trying to force the installation back from Pro to Home just to use the OEM license that came with the ASUS. Edition changes in that direction aren't generally a simple in-place switch, and in this particular situation a reinstall could create much more work because you'd have to rebuild your accessibility configuration and application environment.

Before buying anything, though, I'd check the exact activation status under Settings → System → Activation and also see whether Windows reports that the device has a digital license or an embedded Home key. If the old Windows 10 Pro license was legitimately yours, it may also be worth checking whether it can still be transferred or reactivated rather than immediately purchasing another license.

If you do end up needing a Pro license, I'd stick with Microsoft or a reputable authorized retailer rather than one of those extremely cheap product-key sites. Saving a few dollars isn't particularly useful if the key later turns out to be invalid.

Given the accessibility issue, I'd definitely back up your important data before making any edition or licensing changes. But I would start by trying to activate the existing Windows 11 Pro installation, rather than reinstalling Windows.