Graph http 449 throttled

We are experiencing a lot of Microsoft Graph trolling errors from some of our applications that are hosted in Azure Web App Services and other third party such as Front App to name one. I am trying to find an approach or strategy to figure out and narrow down what may be causing so many of these events. Whether I can narrow down by application or process, I am not sure yet. We enforce MFA on all our users, but of course, on Azure Enterprise Applications, we don't, which are used extensively in our ecosystem of apps. Any help is much appreciated here.