503 Service unavailable

Dear Team,

I am using Exchange server 2016 enterprise edition. 

2 Nodes are primary

2 Nodes are DR

all nodes are in DAG. Now i am facing problem after 6 hours later, my OWA/ECP/OUTLOOK services shut. When i open the web https://exch-01/ecp it said 503 Service unavailable. Its coming on random nodes.

Please,help me with this.