Registry is mess. How can I clean registry in windows 10?

The official stance from Microsoft and most IT professionals is that manual registry cleaning is almost never necessary for modern Windows (10 & 11). The performance gains are typically negligible or non-existent. The primary cause of a "messy" registry is simply having installed and uninstalled many programs, which leaves behind harmless orphaned entries.

You can now clean registry in windows 10 by uninstalling programs properly. The biggest source of registry clutter is leftover entries from poorly uninstalled software.

1. Go to Settings > Apps > Apps & features.

2. Sort by size or date and uninstall any applications you no longer use. This will remove most of their associated registry entries correctly.

3. For more stubborn applications, use a dedicated uninstaller tool like Revo Uninstaller (Free Version). After running the program's built-in uninstaller, Revo will scan for leftover files and registry entries and allow you to safely remove them. This is far safer than manually hunting in the registry.