Random files not opening in fresh Windows 10 Enterprise installation

Hi folks, been a long time since I visited here, I hope everyone is doing well and has happy holidays this year.
So I have a Windows 10 enterprise, installation and:

1 I turned off a lot of analytics in this install, all before I turned on the internet access.
2) Now when I click on some random files (but not every file), I get a quick small blank popup for a fraction of a second, and the file doesn't open. (this was happening before I turned the internet on, and is still happening afterwards).
3) One of the files that was blinking out was throwing a Microsoft popup from the right side of the screen and when I clicked on it, it said Windows was not allowing it to run, so I click on that window and turned that one off. Well the random files keep shutting down anyway.

Anyone here have a fix or at least an explanation for what might be happening?