Forum Discussion
SharePoint 2019 User Profile --> Manage User Permissions
gojo12, We did login with the farm account on the server. Its not best practice, but the only solution. Also what we notices is that when you change the url of the Mysite Host Location to for example http://fakeurl then you can make the notification. So it looks something related to permissions on the mysite web app itself.
I believe you have to add your account to the User Profile Service Application settings. Go to Central Admin > Manage Service Applications (/_admin/ServiceApplications.aspx). Select the User Profile Service Application, and in the ribbon click Administrators. Then type in you account, click Add, select your account in the user list below, check "Full Control" (which includes the options for Manage Profiles, Manage Audiences, Manage Permissions, Retrieve Data for Search Crawlers, and Manage Social Data), and click Okay. You should now be able to Manage Permissions.
As an aside, make sure you use a service account to crawl your content. You'll also add that service account to the User Profile Service Application Administrators, and give it the Retrieve Data for Search Crawlers permission level only.
HTH