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Change in UPN changes URL to OD4B and requires new setup and new sync...
We are in the planning stages of changing the UPN (universal principle name) in users active directory accounts (not changing SAM account name, just UPN) so that users can have a better experience wh...
We did run into that issue.
What helped as resolution was
1st) stop OneDrive for business client (onedrive.exe)
2nd) Open regedit
3rd) [HKEY_CURRENT_USER\SOFTWARE\Microsoft\OneDrive\Accounts\Business1]
Update following key "UserEmail"=mail@organization.com to the new UPN in our case the SMTP address
4th) restart OneDrive for business and try to register it again