Unable to "Open in Excel", "Open in Word", etc from SharePoint Online in Chrome

It might be caused by one of following two reasons:

1. Hanlder not registered.

You can confirm it out by two ways: 1) If you are in edit mode, switch your word online into "view mode"(view -> reading view) and click "edit in word". 2) Go back to sharepoint file list view, select the document and click "open -> open in word" in the top menu.

if handler problem is confirmed, you can follow this link to manully fix it: http://forums.mozillazine.org/viewtopic.php?f=38&t=2899199

Note: the registry value could be different based on the office version, you could find another workable machine for reference.

2. If hanlder is working fine, it might be caused by browser's pop-up blocker, which blocks pop-up in edit mode of word online. You can disable "pop-up" blocker in your browser settings and try it again.

Hope above helps!

Thomas