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Fegume's avatar
Fegume
Copper Contributor
Nov 21, 2023

SmtpResponse: 451 4.4.397 Error comunicating with target host. -> 421 4.2.1 Unable to connect -->

Hello I have:   Server Work: Windows Server 2008 R2 Exchange 2010 Server with issue: Windows Server 2016 Exchange 2016 Domain: Windows Server 2016   I try migrate my Exchange 2010 to Ex...
2010
2016
Exchange Server
AnnTaeYoun's avatar
AnnTaeYoun
MVP
Nov 22, 2023

Fegume 

Is anti-spam feature enabled in Exchange 2010?

  • Fegume's avatar
    Fegume
    Copper Contributor
    Nov 22, 2023
    Hello, @TAE YOU ANN

    Yes the anti-spam is work on Exchange 2010.
    This razon posibility solution for this:
    Exchange 2016 to 2010--> Failed

    but. why can't send email on users the same mailboxdatabase?.
    This example :
    Exchange 2016 to 2016 --> Failed

    Regards!
    • AnnTaeYoun's avatar
      AnnTaeYoun
      MVP
      Nov 23, 2023

      Fegume 

      Please review the hosts file in the C:\Windows\System32\drivers\etc path!
      If there are unnecessary values, remove them and try again!

      Case) If the value of Exchange Server is registered, it needs to be removed.

      • Fegume's avatar
        Fegume
        Copper Contributor
        Nov 28, 2023
        Hello, the etc file is empty

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