Access File Structure for Salesforce Marketing Cloud email lists

I would appreciate suggestions on file structure for setting up an ACCESS data base for my 200 emails lists that are categorized by Major File Titles.  I have 20 file folders with 3 to 60 email lists in each folder and would like to set up an Access data base to be able to easily download files (email lists).

I am new to Access but understand DBMSs from long ago in mainframe days.

Please help me as I must transition email lists soon.

Major file 1

   files with email list 1A

        list 1AA

        list 2AA

   email list 2A

etc.

example from Marketing Cloud

EACH FILE HAS LISTS IN THE FOLDER