“Operating system is not presently configured” error with Access ODBC

rathiaditya 

This looks like a "closing in" issue. I would take the next steps to solve or narrow down the problem:

1. Run it on another machine and see if the problem occurs. 
2. Check for recent Windows and Microsoft Office updates and roll them back if possible.
3. Remove my Microsoft Office installation and install it again.
4. Remove the Microsoft Access Database Engine Redistributable and install it again.
5. Try to update pyodbc: pip install pyodbc --upgrade
6. Try an alternative Python package for connecting to Access. For instance: pypyodbc (https://code.google.com/archive/p/pypyodbc/ ).

Options 5 and 6 are merely solving the symptoms (if they work), rather than solving the problem. But if they fixe the issue, they could save the day.

Good luck and best wishes,

Tieme