Hi Francesco_beqom,
As devakishore mentioned, Always Encrypted with secure enclaves gives you much more flexibility compared to Always Encrypted.
The first version of Always Encrypted didn't use an enclave, so you were limited when you want to use an encrypted column in a where clause.
The enclave allows your to use rich confidential queries and use like, < >, BETWEEN, etc. in the where-clause on encrypted columns. Another advantage of the enclave is that it is used during the initial encryption. So, the data doesn't have to leave the database anymore to perform the initial encryption.
More information on how Always Encrypted with secure enclaves works can be found in our documentation or in this blog post.
Regarding your comment on Dynamic Data Masking and Always Encrypted. That is correct, DDM is not an encryption feature and the data is still in plaintext in the database.