The Readiness Tool is looking for both Device Guard and Credential Guard compatibility. These two warnings are related to Device Guard, so nothing related to Credential Guard is showing as an issue.
For the two issues you are mentioning HSTI is optional, lack of HSTI does not prevent anything from running. The advantage of HSTI is to ensure that teh hardware security capabilites are present and enabled. The incompatible HVCI driver output will be color coded, if yellow there is a potential compatibility issue with hypervisor preotecion of Code Integrity, but in many cases it will still work. If red, then there is a blocking issue.
You can enable Credential Guard and may well be able to enable Device Guard Virtualization Based Security too.