lalanc01​ This comes up a lot during IE-to-Edge migration. Here's the quick breakdown:

• Trusted Sites / Security Zones: These are only honored in IE Mode tabs within Edge. Standard Edge (Chromium) tabs do not use Windows Security Zones. So if you have apps running in IE Mode that depend on Trusted Sites, keep those zone policies. For everything else in regular Edge, they can be removed.
• Proxy settings: Transition to Edge-specific proxy policies via Intune Settings Catalog or Administrative
• Templates (Microsoft Edge > Proxy settings). The legacy IE/Windows Internet Options proxy settings only apply to IE Mode.
• General guidance: Audit which apps still need IE Mode using the Enterprise Mode Site List. For those apps, keep the relevant IE policies. For everything else, migrate to native Edge policies in Intune and remove the legacy IE settings.
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The Settings Catalog in Intune has comprehensive Edge policy coverage that replaces most legacy IE configuration needs.

Hope this helps.