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Joe_Lurie
Microsoft
MicrosoftLOB is more legacy, and only allows simple app installation (MSI, not you can not attach an MST, for example). Win32 allows greater control, including Supercedence, Dependencies, detection...and you can wrap multiple files with the IntuneWin wrapper.
Ultimately, you should test each deployment method and use the one that's right for you.
PS: this isn't the right page for this question. A better page would've been the Windows + Intune Office Hours page here: https://techcommunity.microsoft.com/t5/windows-events/windows-intune-office-hours-at-microsoft-technical-takeoff/ec-p/3652942
As someone who does this for their day job, I would say use win32 always. It's more robust. LoB is less flexible and I've had some disconnect between what it says is installed, and what the workstations say is installed. You can automate the production of the intunewin file to a greater or lesser extent, depending on your Powershell scripting skills.