AMA: Microsoft Connected Cache and Delivery Optimization

There's rarely a one size fits all answer which is why there are choices that you can use to tailor the solution to your environment. Generally though, using DO and MCC "best" is about mapping your content sharing and caching to your network topology and infrastructure which in many/most cases mirrors the DHCP scopes in an environment and thus using DHCP often works "best" and is also the easiest to implement. Your mileage may vary though :-)