The Store of the future

If a device is enrolled for Autopatch, then it is already using Windows Update for Business; Autopatch is (more or less) a managed service that leverages Windows Update for Business (and a few other mechanisms) to deploy updates to enrolled devices (there's more to Autopatch than just rolling out updates, but this is the crux of the core functionality). To my knowledge, once a device is enrolled for Autopatch, setting any Windows Update for Business policies through any other means is unsupported and could/will cause issues. Technically, there's nothing that will stop you from doing this just like technically, there's nothing that will stop you from driving down the freeway the wrong way (except for fear of the consequences), but it is unsupported as noted.