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Totally agree, on occasion we have had to use registry keys to fix issues with other Microsoft applications (Office 365, for example). I'd love to not have to use reg keys, but frankly, when Microsoft itself relies on them, it's hard to not leverage that.
Or when a security remediation requires setting a registry key to make a security patch work. You'll see this a lot in MDE and other security patch notes. It would be great if this could be rapidly done via MEM.