Issues with server on domain

So we are having an odd problem with intermittent connectivity on Windows server 2022 install.  It's a repository server, that is also used for dev work so at any one time we have users connected to it from different groups in the US, as well as outside the US (India & Australia).  It is located on on our US domain, and users connect using their AD credentials.  The problem we are seeing is that users outside the US can't connect to the system randomly, but most of the time users in the US can.  However occasionally they have issues too so it's random.

So far we have tried the following to address it, but are still seeing problems:
- We've tried removing and rejoining the domain.
- DNS settings are correct, and are the same as other WS2022 (and 2016 servers) that are also on the domain.
- We are using a corporate NTP server, which is also used by the corporate DC's.
- Firewalls aren't blocking traffic.
- Most recently about 3 weeks ago I did see some GPO errors, so did do a GPO update.  This seemed to help until this past Friday when the issue occurred.  
- We are fairly thorough with maintenance as we have a monthly window after MS patch Thursday to update and reboot the system at least once a month.  

We have a secondary site where this system is replicated, and both of of the vm's were made from the same template...but this system doesn't have the same issues.  Any ideas on what we could be missing or what to look at next?