Recovering from a system-wide icacls reset

Hey guys. So I was trying to fix permissions on a drive for a buddy of mine by running icacls commands on it while it's in an external enclosure. I entered icacls * /reset /T while in a Powershell prompt for the E: drive...and that's when I found out that icacls doesn't respect where you are currently navigated to in the command line.

So in short, I just ****ed my whole computer. Both user profiles I sign into (one personal and one for work) now redirect to temporary profiles. Is there any way to recover from this or am I gonna have to bite the bullet and just reformat? It's not hugely problematic because all my personal files are on a NAS but it's still going to be a LOT of work.

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So I appear to have fixed it by changing permissions on both user folders. On the root folder for each user I selected Properties > Security > Advanced, then I added the correct user with full permissions (left the owner as the "Administrators" group), disabled inheritance, then replaced all child object permissions. I also removed "Everyone" from read + execute.

Everything seems to be functioning properly but I may run into problems going forward, we'll see. There were a couple "access denied" files in the user folders, I assume they were some kind of weird dynamic caching files or whatever.