MDS and React

were you doing something similar to below:

if ("undefined" != typeof g_MinimalDownload && g_MinimalDownload) {
// Register script for MDS if possible
console.log('MDS enabled.');
RegisterModuleInit( _spPageContextInfo.webAbsoluteUrl + "/Style Library/MDS.js", RemoteManager_Inject); //MDS registration
console.log('Register Module after Init');
NonMDS(); //non MDS run
} else {
console.log('MDS not enabled.');

NonMDS();
}
function NonMDS(){
console.log('Non MDS run...');
}
function RemoteManager_Inject() {
console.log('Remote Manager Inject');
}