Why so many MS Edge entries in Open with menu on macOS

Think I found the problem. Here's what worked for me.

As I mentioned in a previous comment, I used AppCleaner (free utility that thoroughly removes applications and their associated files) for uninstallation. However, something must have gone wrong during the cleanup process, as I still discovered a folder containing over 15GB of Edge-related files. I found these remnants using these commands:

sudo find /private/var/folders/ -name "*Edge*"
sudo find /Library/Application\ Support -name "*Edge*"
sudo find ~/Library/Application\ Support -name "*Edge*"

This led me to this folder:

~/Library/Application Support/Microsoft/EdgeUpdater

After removing any found files and emptying the Trash, rebuild the Launch Services database by using:

/System/Library/Frameworks/CoreServices.framework/Versions/A/Frameworks/LaunchServices.framework/Versions/A/Support/lsregister -kill -r -domain local -domain user;killall Finder;echo "Open With has been rebuilt, Finder will relaunch"

and then follow up by rebooting your Mac.

This should permanently remove all duplicate Edge entries from your "Open With" menu. The issue seems to stem from Edge's update system storing multiple versions, which aren't properly cleaned up during uninstallation.