Applications are not correctly detecting .NET Desktop Runtime 6.0.1 (x64)

Even though I have .NET Desktop Runtime 6.0.1 (x64) installed, I'm still getting an error when launching a .NET application

Windows 10 21H2 OS Build 19044.1466

Event log shows event 1023 - Description: A .NET application failed.
Application: HandBrake.exe
Path: C:\Program Files\HandBrake\HandBrake.exe
Message: Failure processing application bundle.
Bundle header version compatibility check failed.
A fatal error occured while processing application bundle