MariaDB/MySQL Master/Master database replication across regions on Microsoft azure Environment

We would like to implement geo redundant MariaDB Active/Active Database replication on Microsoft azure Environment. Scenario is as under:

There would be a scale set/availability set of Mariadb Database virtual machines in two zones of region 1. There would be a scale set/availability set of Mariadb Database virtual machines in two zones of region 2.

Our requirement is to configure database replication across zones as well across regions. This High availability scenario will provide us Geo redundant database replication. Any help regarding this would be appreciated.