Justin Coffey This challenge of providing guidance for the tenant topology a commercial customer has is less than trivial. In fact, I wrote an article on it found here: The Microsoft 365 US Government (GCC High) Conundrum - DIB Data Enclave vs Going All In
Even if the majority of the company's business is not subject to data handling of CUI/CDI, they can put any data that is non-classed into GCC High. We always recommend keeping to a single tenant if at all possible. The collaborative experience is much better in a single tenant, plus it reduces complexity over having to straddle two or more tenants. Microsoft will close the gap on feature parity challenges, such as B2B Guest access in the 2020 timeframe. However, we do have reference architecture for those scenarios where a many-tenant topology is required. They are not published publicly at this point, as it contains some NDA content. We are happy to share it with you, if you reach out directly. We can setup a working session to cover them.