Blog Post

Healthcare and Life Sciences Blog
2 MIN READ

Microsoft Azure continues to expand scalability for Healthcare EHR Workloads

MikeL's avatar
MikeL
Icon for Microsoft rankMicrosoft
Nov 11, 2025

Microsoft Azure has reached a new milestone for Epic Chronicles Operational Database (ODB) scalability with the Standard_M416bs_v3 (Mbv3) VM. It can now scale up to 110 million GRefs/s (Global References per second) in the ECP configuration and up to 39 million GRefs/s in the SMP configuration, improving upon the previous Azure benchmarks of 65 million GRefs/s and 20 million GRefs/s respectively.

Microsoft Azure now can host 96% of the Epic customer base, enabling healthcare organizations to run their EHR systems on Azure.

New VM Size Purpose-Built for Epic’s Chronicles ODB

The Standard_M416bs_v3 VM, newly added to Azure’s Mbv3 series, is purpose-built to meet the growing performance and scalability demands of large healthcare EHR environments. With higher CPU capacity, expanded memory and improved remote storage throughput, it delivers the reliability needed for mission-critical workloads at scale.

Key specifications include:

  • Mbv3 Processor Performance: Built on 4th Gen Intel® Xeon® Scalable processors, the Mbv3 series is optimized for high memory and storage performance, supporting workloads up to 4 TB of RAM with an NVMe interface for faster remote disk access.
  • Compute Capacity: The Standard_M416bs_v3 delivers 416 vCPUs - more than twice the capacity of previous Mbv3 sizes, delivering stronger performance.
  • Storage Performance: Achieves up to 550,000 IOPS and 10 GBps remote disk bandwidth using Azure Ultra Disk.
  • Performance Optimization: Enhanced by Azure Boost, the M416bs_v3 provides low-latency, high remote storage performance, making it ideal for storage throughput-intensive applications such as Epic ODB, relational databases and analytics workloads.
  • Available Regions: M416bs_v3 is available in 4 regions - East US, East US 2, Central US, and West US 2.

 

Explore Epic on Azure to learn more.  


Epic and Chronicles are trademarks of Epic Systems Corporation.

Updated Nov 11, 2025
Version 1.0

1 Comment