If you don't want or need external access (clients connecting from the internet) you don't need to change anything. Just add your internal URL's as SPN's in AAD and it'll work fine. AAD can and will issue tokens for those URL's if they are configured in the tenant.
The clients will talk to Exchange over the local network, then head to AAD to get a token, then back to Exchange. Your clients need to be able to reach AAD from your internal network.
If you do want to allow external access to Exchange, you need to an valid externalURL's to /mapi, /ews, /oab, make sure there's a certificate with all the right names in place on Exchange (or some proxy device if you use one) and register those URLs in AAD too.