Thanks Gregor. I don't work with GPOs on a daily basis so I tend to forget. But as long as I have the basics, down I think I will be fine.
The documentation I read says that you can filter out who a GPO applies to by using "Security Filtering" and/or Delegation (The delegation Tab) in GPMC.
Do you often do that? Or do you just control who a GPO applies to by linking the desired GPO to the desired OU? It seems like you do it that way. I am just trying to make sure I understand many of the In's and Out's of GPO design.