Non Persistent VDI - Slow Slow Slow ;-)

Hey,

We are facing some challenges with Defender as it massively slows down our CRM workflows.

We are using a VMWare Horizon Instant Clone setup with Windows 10 (21H1) VDIs.

Updates for the CRM or Workflows like loading a Template from a network share takes a crazy amount of time. Task Manager tells me its either Antimalware Service or ATP Service which starts to create high CPU usage. We tried to work with exceptions but it seems it doesnt care at all for it. 

As an example an update without Realtime Scan takes 35 Seconds. With Real Time Scan enabled it takes 3 Minutes.

Can someone help me on that challenge?