First published on MSDN on Apr 08, 2008
Occasionally different anti-virus products can interfere with SharePoint operations. The following is a list of suggested locations to exclude from your AV scanner. Remember, this is merely a suggestion, so use at your own risk!
1. %PROGRAM FILES%\Common Files\Microsoft Shared\web server extensions\12
2. %WINNT%\temp
3. %PROGRAM FILES%\Microsoft Office Server
4. %WINNT%\Microsoft.NET\Framework\v2.0.50727\Temporary ASP.NET Files\
5. Documents and Settings\All Users\Application Data\Microsoft\SharePoint\Config\ (the config cache)
6. %WINNT%\Temp\WebTempDir
UPDATE : We've released a KB that covers this.
http://support.microsoft.com/kb/952167
