SQL Server 2017 – CLR was loaded in an unsupported manner (All SSIS jobs failed)

Hi,

We are facing a critical issue in our SQL Server 2017 instance.

When trying to use a built-in CLR function or running SSIS-related jobs, we are getting the below error:

The Common Language Runtime (CLR) was loaded in an unsupported manner.
This can occur if an extended stored procedure or OLE Automation object running in SQL Server
calls into managed code before the CLR integration runtime host loads the CLR.
You need to restart SQL Server to use CLR integration features.

Steps tried so far:

Restarted SQL Server service

Restarted the entire Windows Server

Verified .NET Framework version (4.7.03062 installed)

Confirmed CLR integration is enabled (sp_configure 'clr enabled', 1)

All SSIS jobs are failing due to this issue.

Any suggestions, please?