WSL2 Defender Endpoint

In case you are subscribe to Microsoft 365 Defender or Microsoft Defender for Endpoint Plan 2, you may deploy Microsoft Defender for Linux and in case your distribution of Linux is in the supported list, it should work.
Take a look at:
https://docs.microsoft.com/en-us/microsoft-365/security/defender-endpoint/microsoft-defender-endpoint-linux
https://docs.microsoft.com/en-us/microsoft-365/security/defender-endpoint/linux-install-with-ansible