Modern Unified MsSense.exe and CPU/disk usage on 2012 R2 after March updates

I had the same issue after upgrading to the Unified Agent and updating the Sense client to 10.8048.22439.1065. Updating to - KB5005292 (Version 10.8049.22439.1084) seems to have fixed it for me. You can get the updated Sense Client from https://www.catalog.update.microsoft.com/Search.aspx?q=KB5005292

and verify that Client has updated by running the following PowerShell command

Get-WinEvent -FilterHashtable @{ProviderName="Microsoft-Windows-Sense" ;ID=1}