EnableFileHashComputation

It is confusing, this forum is for MS Defender for Endpoint, which is not the same as Microsoft Defender Antivirus. That said, MDE logs file hashes for process created events through some other mechanism (we are using MDE but do not have this MDAV setting turned on.) and we have not seen any ill effects. Other host level AV type tools or EDRs like Microsoft's own Sysmon also do hash calculation. So hard to see how turning this on in MDAV could be any different. If you have intensive software development work, it is probably already given an MDAV exclusion anyway, so in practice that particular risk is mostly moot.