Enable Network Protection - Error "-2147467259" - Windows Server 2016

I've seen this, or a very similar error code in Intune/Defender for Endpoint several times now. In my case it seems infrequent and random. The configuration profile or compliance policy will work on >95% of systems but fail here and there with an error like this. I think it must be due to some kind of integer overflow, 2147467259 seems far too close to 2147483648 (half the maximum value of a 32bit integer represented in base 10) for it to be a coincidence.

I'd be very interested if anyone here knows more about these errors, especially if there is a way to avoid them.

Cheers,
Tyler