Problem with E drive

Hi.

I have what looks  to be a software issue on E:\ drive, but when I contacted Microsoft live chat support they are saying it looks more like a hardware problem, but the error says it's about either a missing App, or an association problem.

I can't attach a screenshot, or copy/paste, but this is the error that shows:-

 E:\  This file does not have an app associated with it for performing this action. Please install an app or, if one is already installed, create an association in the Default Apps Settings page.

I don't have a clue what this means, or even where to look.

It's a fairly new system, I only got it in Feb this year.

This has only just very recently started happening. I am getting the attached error whenever I use either an SD card reader, or the External drive.

I've tried several different cards, and different readers, in most of my USB ports.

This makes using any external drive a bit glitchy.

Is there any way that anyone can help, or any suggestions where to look?

I really need this drive working properly. 

Thanks.

Steve.