ChristianSchindler Today, DoH and DoT are not supported by the Windows DNS server which means ZTDNS during preview relies on third-party DNS servers. However, I know the owners of the Windows DNS server and they've said that they plan to support DoH in a future version of Windows Server.
 
To your other point, yes, and calling it a hassle is putting it lightly. It is expected that getting ZTDNS fully deployed in enforcement mode will be a long-term journey that starts with testing it out in audit mode (logging, but no enforcement) to discover the real-world name dependencies your network has, and slowly building up allowlists and attempting to reduce the unknown lists (not explicitly allowed but not blocked either). It isn't a feature for everyone, but for enterprises with high compliance expectations, it will be a unique tool in their Zero Trust toolkit that will be worth the ROI.