Darryl, I checked with the ISA team and their answer was:
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YES, if you have multiple Exchange Front End/CAS servers you can create a server farm on ISA. The topic, "Publishing Exchange Server 2007 with ISA Server 2006" has documentation about that at http://www.microsoft.com/technet/isa/2006/deployment/exchange.mspx. The topic below was an example they provided.
Create a server farm (optional)
When you have more than one Exchange front-end server, you can use ISA Server to provide load balancing for these servers. This will enable you to publish the Web site once, instead of having to run the wizard multiple times. Also, this eliminates the need for a third-party product to load balance a Web site. If one of the servers is unavailable, ISA Server detects that the server is not available and directs users to servers that are working. ISA Server verifies on regular intervals that the servers that are members of the server farm are functioning.