@Mikhail: The Mail Submission service notifies Hub Transport servers in the same Active Directory site. The Store driver on the Hub Transport server retrieves the message from the Mailbox server and places it in the Submission queue.
More details in http://technet.microsoft.com/en-us/library/aa998825.aspx
Understanding Message Routing > http://technet.microsoft.com/en-us/library/aa998825.aspx#MessageRouting
Receiving Messages for Routing > Retrieving Messages from a Mailbox Server
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