I have a suggestion, if your rule can identify this prior to the e-mail being sent could the rule provide lesson's learned of best practice's? For example in the company that I work for there could be several people or directories that would need to track the information. I have learned that the people or the directories that need to track the information in the To: line, and the people that I need the response from I put the Distro-List in the BCC: Line. That away when they do use the "Reply All" it only goes to the sender and the important people that need to track the responses. From my experience I could see where this rule could hinder an operation, if the rule's criteria was met and the rule locked people out for 4 hours.
If a company has over a million employee's 5,000 could be hit pretty easy. Would this rule identify e-mail address that are redundant in different DITRO-List? or Would it just count total number of address?