We applied 5v2 to one of our Exchange 2010 SP2, rolup 4v2 servers today running the CAS and HT roles. It literally took 4 hours to run. We did verify that the IE check certificates was unchecked (the update informs you of this condition if it isn't selected). After it ran, OWA stopped working. It just displayed a "page could not be displayed" error. The second (and fortunately active) CAS server did not experience any issue. Since we could not confirm the update was applied successfully, we uninstalled it (which fortunately only took like 10 minutes). A reboot later and OWA started working again. There is definately a problem with rollup 5v2. Do we need to update all of the CAS servers in the org in order to have OWA work? Why did applying the update take so long? What did we do wrong? We really want to get the latest updates installed, but we need OWA working.