On my first attempt at installing Rollup 4, it failed. I rebooted and couldn't connect to anything as far as Exchange management goes. Was getting WINRM errors via the shell and EMC wouldn't connect. So, I ran the update again. This time it succeeded and I rebooted. Still, no connectivity to Exchange.
I noticed that ALL the exchange services were set to Disabled, as well as W3SVC/IISADMIN and a few others. I also read some threads about reinstalling WINRM. Turns out, it was not installed on the server. I installed it and then ran "winrm quickconfig." Then I set all the Exchange services to Automatic and started them all manually. Did the same for W3SVC and IISADMIN. I compared the services on another 2008R2 server to make sure everything else was set as it should be.
Rebooted, and everything came back. So far so good. [knocks on wood.]