@FYDIBOHF25TVDLT: as far as I can say until now - there are no problem for the user resulting from the error. But of course it makes the logfile hard to read.
I found a second Event in the application eventlog of our servers with the Mailbox role (this is not new with SP2 RU3 but it is anoying, too):
Event Number: 106
Source: MSExchange Common
Fehler beim Aktualisieren eines Leistungsindikators. ... Last worker process info : System.UnauthorizedAccessException: Der Zugriff auf den Registrierungsschlüssel "HKEY_LOCAL_MACHINESOFTWAREMicrosoftExchangeServerv14Transport" wurde verweigert.
...
The server has only the Mailboxrole - so it is no wonder that the "...Transport" key in the registry does not exist. Why does exchange try to renew an performancecounter at this key on an pure Mailbox server?