We are aware of the registry key. It is a temporary relief, and it is not "unsafe" for your server. But it might not be the final way to solve this either.
We are still waiting for the official guidance from Windows team and will provide it when we have it. I know it might seem pedantic, but while we want to provide guidance to Exchange customers, we need to get the right guidance from Windows team in this case, as it is a Windows update that changed the setting here.
It is not a satisfying answer for anybody; as soon as I have official guidance that we can share and has been bought off, we will share it.
Also please note that not nearly every server will run into this problem; this has to do with server peak load and exhaustion of resources over time (which is why a reboot solves the problem for a while). Some Exchange servers will never see the problem at all.