I got some catching up to do; thanks to everyone who has been answering questions! 🙂
HYper83 Yes, if you have E2016 CU18 and then install the security patch and then install E2016 CU19, you will have to install the CU19 security patch after CU19 is installed.
Marc4056 Yes on Edge. No on Management tools
DMoenks Run the Health Checker script, it will tell you; but if you ran the install (from elevated CMD prompt, or from Microsoft Update) and it installed with no errors, you are good!
marceloi750 Please reboot the server before trying to install; possibly something has a handle on that file. Do you use a file-level AV software that might be doing that? Then, when you are installing the update, make sure you are running it from elevated CMD line