Two notes from our initial testing of SP1:
1. NET 4.5.1 System.Web.HttpModule based extensions do not work in the /mapi/emsmdb page, either failing or causing the MapiHttpHandler to fail, depending on the extension implementation. It appears to be the same bug that was corrected in the WCF server framework described in http://blogs.msdn.com/b/praburaj/archive/2012/09/13/accessing-httpcontext-current-request-inputstream-property-in-aspnetcompatibility-mode-throws-exception-this-method-or-property-is-not-supported-after-httprequest-getbufferlessinputstream-has-been-invoked.aspx). Would definitely like to see this one fixed.
2. IIS Advanced Logging does not work on the Exchange Backend/mapi/emsmdb page. It does work properly on the ews, owa and rpcProxy.
John